A new chemotype with promise against Trypanosoma cruzi
نویسندگان
چکیده
منابع مشابه
New thiadiazine derivatives with activity against Trypanosoma cruzi amastigotes.
The cytotoxicity of 18 new 1,2,6-thiadiazin-3,5-dione 1,1-dioxides was evaluated. This group of products was previously assayed against epimastigotes of Trypanosoma cruzi and some of them showed a high antiprotozoal activity. Thereafter 13 compounds with a high anti-epimastigote activity and low cytotoxicity were selected to be assayed against amastigotes. Some of the products showed the same o...
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Upon infection, Trypanosoma cruzi triggers a strong immune response that has both protective and pathological consequences. In this work, several important questions regarding protective immunity are reviewed. Emphasis is placed on recent studies of the important protective role of CD8+ T cells and on previous studies of immunisation of domestic T. cruzi reservoirs that sought to address practi...
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The current pharmacological Chagas disease treatments, using Nifurtimox or Benznidazole, show limited therapeutic results and are associated with potential side effects, like mutagenicity. Using random screening we have identified new chemotypes that were able to inhibit relevant targets of the Trypanosoma cruzi. We found 3H-[1,2]dithioles with the ability to inhibit Trypanosoma cruzi triosepho...
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Background: Some of medicinal plants are a potential source of new drugs to improve the treatment of Chagase disease whose treatment is still a challenge. Here in this screening, the in vitro trypanocidal activity of some fractions for 16 medicinal plants, collected from the northern part of Iran, has been reported. Methods: Aerial parts of the plants were dried carefully and followed by ex...
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Parasitic diseases are widespread in less developed countries, and are a major cause of suffering and inability of the affected populations to improve their own living conditions. Among these diseases, American trypanosomiasis (Chagas' disease), due to the kinetoplastid protozoon Trypanosoma cruzi, is particularly relevant to Latin America. The natural products literature mentions a wide variet...
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ژورنال
عنوان ژورنال: Bioorganic & Medicinal Chemistry Letters
سال: 2020
ISSN: 0960-894X
DOI: 10.1016/j.bmcl.2019.126778